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Jung SM, Hung C-M, Hildebrand SR, Sanchez-Gurmaches J, Martinez-Pastor B, Gengatharan JM, et al

Self-reported community protocols commonly describe once-daily dosing with on/off cycling, motivated partly by the absence of any long-term human safety data and partly by a community perception of diminishing returns or tolerance over continued use

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Immunofluorescent staining of human testes revealed that FOXO4 expression was primarily localized to the interstitial or peritubular cells, but not within the seminiferous tubules